Zebrafish-related positions


Postdoctoral position. Centro Andaluz de Biología del Desarrollo (CABD), Seville. Juan R. Martinez-Morales Lab

posted Aug 17, 2018, 8:30 AM by Flavio Zolessi

Postdoctoral position. Centro Andaluz de Biología del Desarrollo (CABD), Seville.
Juan R. Martinez-Morales Lab (jrmarmor@upo.es) is recruiting competitive
postdoctoral researchers to participate in an interdisciplinary project on comparative
tissue morphogenesis.

Research project/ Research Group description:
The main focus of our laboratory is to study cellular and molecular mechanisms
involved in the morphogenesis of the vertebrate eye. Using the teleost models
zebrafish and medaka, we investigate the machinery driving the folding of the retinal
neuroepithelium. Optic cup morphogenesis is an atypical model for epithelial
morphogenesis for, in contrast to well-known apical constrictions, it involves the folding
of the tissue towards its basal surface. Although it is generally accepted that optic cup
formation follows a tissue-intrinsic program in vertebrates, several mechanisms have
been postulated (basal constriction, rim involution) and some important differences in
cell behaviour have been reported among species. Many important questions still
remain open. Which is the relative contribution of each mechanism to the folding of the
optic cup? Do they act in a cooperative manner? Do they have the same regulatory
weight in different species? To answer these questions, we aim to integrate genetic
information, imaging analysis of cell shape changes, and tensional forces distribution
into coherent computational models able to predict the key morphogenetic rules that
shape the entire organ. We plan to extend our observations to mammalian tissue, by
examining cell shape changes and tensions in 3D retinal organoids developed in vitro.
A key aspect of the project is to understand how classical signalling events, which have
proved to be essential for the proper patterning of the organ, act in coordination with
tensional forces. This highly interdisciplinary approach, combining genetics, imaging,
biophysics and computational modelling should yield information relevant not only to
understand optic cup formation, but also to deduce general self-organization principles
of the living matter.
Last Publications: Letelier et al. (2018a) Nat Genetics, Letelier et al (2018b) PNAS, Nicolás-
Pérez et al (2016). eLife; Gago-Rodrigues et al (2015). Nat Comm ; Tena et al (2014)  Genome
Research. 24(7):; Bogdanovic et al (2012). Developmental Cell. 23 (4). For a full list:
https://www.ncbi.nlm.nih.gov/pubmed/?term=Martinez-morales+JR

Job position description:
We offer a one-year renewable contract and full support to apply for external funding.
Given the interdisciplinary character of the project above described, we are seeking
talented and highly motivated postdoctoral researchers with a background either in
Developmental Biology or in Biophysics. Previous experience with teleost models will
be well received. The candidates should have good communication skills, critical for
ensuring the success of the team effort. We offer an adequate environment to mature
scientifically and eventually to become independent scientists. The CABD is
thematically focused on the topic of Cellular and Developmental Biology, and is well
equipped in terms of infrastructure, particularly for imaging analyses. Our research unit,

the department of Gene Regulation and Morphogenesis was recently awarded with the
María de Maeztu distinction of excellence. A series of external seminars by prominent
Spanish and international speakers are organized on a weekly basis. In addition, a
biweekly series of seminars allow PhD students and postdoctorals to present their
work. English is the official language in the CABD as well as in our internal seminars,
as international researchers are frequent visitors/members in our group.
Contact information:
Juan R. Martínez-Morales.
Gene regulation and Morphogenesis Department
CABD. (CSIC/UPO).
Seville, 41013
Spain.
Email: jrmarmor@upo.es
Phone: + 34 954977827
Web pages :
http://cellcollectives.com/dt_doctors/control-of-epithelial-morphogenesis-in-vertebrates/
http://www.cabd.es/en-research_groups-97-221-control-of-epithelial-morphogenesis-in-vertebrates-summary.html

Postdoctoral position at Stowers, USA

posted Jun 6, 2018, 8:28 AM by Flavio Zolessi   [ updated Jun 6, 2018, 8:30 AM ]

Postdoctoral Research Associates
The Bazzini lab at the Stowers Institute for Medical Research (http://www.stowers.org/) has an opening
for postdoctoral researcher to address fundamental questions in RNA biology related to how genes are
regulated and how that regulation controls vertebrate development.
The lab is particularly interested in unraveling: how translation can affect mRNA stability (Bazzini et al,
EMBO, 2016); how mRNA translation is regulated during development by molecular factors such Long Noncoding
RNAs, microRNAs and RNA binding proteins (Bazzini et al, Science, 2012); and identifying the
biological role of small translated ORFs in vertebrates (Bazzini et al, EMBO, 2014).
Candidates will be using zebrafish embryos and human cells, performing genome-wide gene expression
analyses at mRNA (RNA-sequencing) and translational levels (ribosome profiling). CRISPR-Cas9 system will
be intensively used for genome editing as well as multiple molecular biology techniques.
Computational biology knowledge, including command of UNIX and R or other programming languages
and experience in handling large-scale sequence data would be ideal.
Candidates MUST have the ability to work in a team-oriented environment.

To apply, please submit a cover letter (less than a page) that includes a short summary of interests, a CV
(3 pages max) and the contact information of 3 professional references to Dr. Ariel Bazzini.


Applications will be reviewed until positions are filled. The positions are available from October 1, 2018
About the Stowers Institute for Medical Research
The Stowers Institute for Medical Research in Kansas City, Missouri* is a non-profit, basic biomedical
research organization dedicated to improving human health by studying the fundamental processes of life.
Jim Stowers, founder of American Century Investments, and his wife, Virginia, opened the Institute in 2000.
Since then, the Institute has spent over 900 million dollars in pursuit of its mission.
Currently, the Institute is home to almost 550 researchers and support personnel; over 20 independent
research programs; and more than a dozen technology-development and core facilities. Kansas City is an
emerging metropolitan city in the Midwest with a high quality of living and affordability.
*Visit https://www.visitkc.com for information about living and working in Kansas City.

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